Функции белка
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Белок представляет собой часть так называемой Tol/Pal системы белков,
включающей при инвазии клетки Escherichia coli. По-видимому его функция здесь заключается в связывании токсинов и дальнейшей передаче
трансмембранному компоненту системы, который выводит токсин за пределы клетки.
The uptake of colicin U into sensitive cells is dependent on the Tol system. Like colicin A and
the E-type colicins, colicin U contains the consensus pentapeptide DG(T/S)G(S/W) in the N-termin
al 36 amino acids, which have been proposed to be involved in the interaction of colicin U with
the Tol proteins. The role of the DGTGW motif in colicin U was studied by converting it into the
TonB box motif DTMVV of colicin B. Uptake of the mutated colicin U (DTMVV) depended on TonB and
ExbB and still remained TolA- and TolQ-dependent, but no longer required TolB. The Ton system
could obviously replace the TolB function in the uptake of the mutated colicin U. The colicin U
derivative is the first colicin whose uptake depends on the Ton and the Tol systems.
The uptake of colicin U into sensitive cells is dependent on the Tol system. Like colicin A
and the E-type colicins, colicin U contains the consensus pentapeptide DG(T/S)G(S/W) in the
N-terminal 36 amino acids, which have been proposed to be involved in the interaction of colicin
U with the Tol proteins. The role of the DGTGW motif in colicin U was studied by converting it
into the TonB box motif DTMVV of colicin B. Uptake of the mutated colicin U (DTMVV) depended on
TonB and ExbB and still remained TolA- and TolQ-dependent, but no longer required TolB. The Ton
system could obviously replace the TolB function in the uptake of the mutated colicin U. The
colicin U derivative is the first colicin whose uptake depends on the Ton and the Tol systems.
Переход на главную страничку здесь.