ID   PO5F1_PANTR             Reviewed;         360 AA.
AC   Q7YR49; Q1XHV2;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   22-SEP-2009, entry version 47.
DE   RecName: Full=POU domain, class 5, transcription factor 1;
DE   AltName: Full=Octamer-binding transcription factor 3;
DE            Short=Oct-3;
GN   Name=POU5F1; Synonyms=OCT3, OTF3;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=22709134; PubMed=12799463; DOI=10.1073/pnas.1230533100;
RA   Anzai T., Shiina T., Kimura N., Yanagiya K., Kohara S., Shigenari A.,
RA   Yamagata T., Kulski J.K., Naruse T.K., Fujimori Y., Fukuzumi Y.,
RA   Yamazaki M., Tashiro H., Iwamoto C., Umehara Y., Imanishi T.,
RA   Meyer A., Ikeo K., Gojobori T., Bahram S., Inoko H.;
RT   "Comparative sequencing of human and chimpanzee MHC class I regions
RT   unveils insertions/deletions as the major path to genomic
RT   divergence.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7708-7713(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16702430; DOI=10.1534/genetics.106.057034;
RA   Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M.,
RA   Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K.,
RA   Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y.,
RA   Meyer A., Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K.,
RA   Gojobori T., Inoko H., Bahram S.;
RT   "Rapid evolution of major histocompatibility complex class I genes in
RT   primates generates new disease alleles in humans via hitchhiking
RT   diversity.";
RL   Genetics 173:1555-1570(2006).
CC   -!- FUNCTION: Transcription factor that binds to the octamer motif
CC       (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and
CC       controls the expression of a number of genes involved in embryonic
CC       development such as YES1, FGF4, UTF1 and ZFP206. Critical for
CC       early embryogenesis and for embryonic stem cell pluripotency (By
CC       similarity).
CC   -!- SUBUNIT: Interacts with UBE2I and PKM2 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus. Note=Expressed in a diffuse and
CC       slightly punctuate pattern (By similarity).
CC   -!- DOMAIN: The POU-specific domain mediates interaction with PKM2 (By
CC       similarity).
CC   -!- PTM: Sumoylation enhances the protein stability, DNA binding and
CC       transactivation activity. Sumoylation is required for enhanced
CC       YES1 expression (By similarity).
CC   -!- SIMILARITY: Belongs to the POU transcription factor family. Class-
CC       5 subfamily.
CC   -!- SIMILARITY: Contains 1 homeobox DNA-binding domain.
CC   -!- SIMILARITY: Contains 1 POU-specific domain.
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DR   EMBL; BA000041; BAC78165.1; -; Genomic_DNA.
DR   EMBL; AB210197; BAE92816.1; -; Genomic_DNA.
DR   EMBL; AB210198; BAE92818.1; -; Genomic_DNA.
DR   STRING; Q7YR49; -.
DR   Ensembl; ENSPTRT00000033151; ENSPTRP00000030631; ENSPTRG00000017953; Pan troglodytes.
DR   HOVERGEN; Q7YR49; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:transcription factor activity; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR001356; Homeobox.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR012287; Homeodomain-rel.
DR   InterPro; IPR013847; POU.
DR   InterPro; IPR015585; POU_dom_5.
DR   InterPro; IPR000327; POU_specific.
DR   Gene3D; G3DSA:1.10.10.60; Homeodomain-rel; 1.
DR   PANTHER; PTHR11636:SF15; POU_5; 1.
DR   Pfam; PF00046; Homeobox; 1.
DR   Pfam; PF00157; Pou; 1.
DR   PRINTS; PR00028; POUDOMAIN.
DR   ProDom; PD000010; Homeobox; 1.
DR   ProDom; PD000583; POU; 1.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00352; POU; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS00035; POU_1; 1.
DR   PROSITE; PS00465; POU_2; 1.
DR   PROSITE; PS51179; POU_3; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Homeobox; Isopeptide bond; Nucleus; Transcription;
KW   Transcription regulation; Ubl conjugation.
FT   CHAIN         1    360       POU domain, class 5, transcription factor
FT                                1.
FT                                /FTId=PRO_0000100750.
FT   DOMAIN      138    212       POU-specific.
FT   DNA_BIND    230    289       Homeobox.
FT   CROSSLNK    123    123       Glycyl lysine isopeptide (Lys-Gly)
FT                                (interchain with G-Cter in SUMO) (By
FT                                similarity).
FT   CONFLICT      6      6       T -> A (in Ref. 2; BAE92816/BAE92818).
SQ   SEQUENCE   360 AA;  38601 MW;  375D4ADB3C01348C CRC64;
     MAGHLTSDFA FSPPPGGGGD GPGGPEPGWV DPRTWLSFQG PPGGPGIGPG VGPGSEVWGI
     PPCPPPYEFC GGMAYCGPQV GVGLVPQGGL ETSQPEGEAG VGVESNSDGA SPEPCTVTPG
     AVKLEKEKLE QNPEESQDIK ALQKELEQFA KLLKQKRITL GYTQADVGLT LGVLFGKVFS
     QTTICRFEAL QLSFKNMCKL RPLLQKWVEE ADNNENLQEI CKAETLVQAR KRKRTSIENR
     VRGNLENLFL QCPKPTLQQI SHIAQQLGLE KDVVRVWFCN RRQKGKRSSS DYAQREDFEA
     AGSPFSGGPV SFPLAPGPHF GTPGYGSPHF TALYSSVPFP EGEAFPPVSV TTLGSPMHSN
//