ID   TRPC_HAEIN              Reviewed;         477 AA.
AC   P46451;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   06-FEB-2007, entry version 48.
DE   Tryptophan biosynthesis protein trpCF [Includes: Indole-3-glycerol
DE   phosphate synthase (EC 4.1.1.48) (IGPS); N-(5'-phospho-
DE   ribosyl)anthranilate isomerase (EC 5.3.1.24) (PRAI)].
GN   Name=trpC; OrderedLocusNames=HI1389.1;
OS   Haemophilus influenzae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=727;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   MEDLINE=95350630; PubMed=7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M.,
RA   Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D.,
RA   Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C.,
RA   Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M.,
RA   Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O.,
RA   Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
RN   [2]
RP   IDENTIFICATION.
RA   Koonin E.V., Rudd K.E.;
RL   Submitted (SEP-1995) to Swiss-Prot.
CC   -!- FUNCTION: Bifunctional enzyme that catalyzes two sequential steps
CC       of tryptophan biosynthetic pathway. The first reaction is
CC       catalyzed by the isomerase, coded by the trpF domain; the second
CC       reaction is catalyzed by the synthase, coded by the trpC domain.
CC   -!- CATALYTIC ACTIVITY: N-(5-phospho-beta-D-ribosyl)anthranilate = 1-
CC       (2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.
CC   -!- CATALYTIC ACTIVITY: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-
CC       phosphate = C(1)-(3-indolyl)-glycerol 3-phosphate + CO(2) + H(2)O.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 3.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 4.
CC   -!- SUBUNIT: Monomer (By similarity).
CC   -!- SIMILARITY: In the N-terminal section; belongs to the trpC family.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the trpF family.
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DR   EMBL; L42023; AAC23036.1; -; Genomic_DNA.
DR   HSSP; P00909; 1JCM.
DR   GenomeReviews; L42023_GR; HI1389.1.
DR   KEGG; hin:HI1389.1; -.
DR   TIGR; HI1389.1; -.
DR   BioCyc; HINF71421:HI1389.1-MONOMER; -.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00134; fused; 1.
DR   HAMAP; MF_00135; fused; 1.
DR   InterPro; IPR013798; Indole-3-GPS.
DR   InterPro; IPR001468; Indole-3-GPS_central.
DR   InterPro; IPR001240; PRAI.
DR   InterPro; IPR011060; RibP_bd_barrel.
DR   Pfam; PF00697; PRAI; 1.
DR   ProDom; PD001511; IGPS; 1.
DR   PROSITE; PS00614; IGPS; 1.
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; Decarboxylase; Isomerase; Lyase;
KW   Multifunctional enzyme; Tryptophan biosynthesis.
FT   CHAIN         1    477       Tryptophan biosynthesis protein trpCF.
FT                                /FTId=PRO_0000154279.
FT   REGION       13    275       Indole-3-glycerol phosphate synthase.
FT   REGION      276    477       N-(5'-phosphoribosyl)anthranilate
FT                                isomerase.
SQ   SEQUENCE   477 AA;  53306 MW;  B1435FAEFA24379E CRC64;
     MMITQDFTKP IDSATVLQKI VLDKAQWVKA KEKEFPLSQF KQNIQNSDRS FYDALAKGTH
     QKPAYILECK KASPSKGLIR AEFNLEEIAN VYKHYASAVS VLTDEKYFQG NFEFLPLVRD
     IVSQPVLCKD FMISEYQVYL ARYYQVDAIL LMLSVVNDET YRVLADLAHS LGMGVLTETS
     NEEEFERALA LGAKIIGVNN RNLHDLTVDL NRVVELTKKY ADCIPADVRI ISESGIYNHK
     QIHQLQKVAH GFLIGSSLMG NQDLNNAVRS VIFGENKVCG LTRAQDVKIV YENGALYGGL
     IFAEHSKRSV SLRQAQELVT AAPLRFVGVF QNQEIDFIVK IASQLQLYAV QLHGAETEAF
     ITALRQQLPK NTQIWKAISV NTEAQSAVDF TDDLNVDRYI FDSQTANQQG GTGKTFDWSL
     IPENLKHKII LAGGISPNNV EQAIAQGCLG LDLNSGVESS AGVKDQEKVR LVFNNIY
//