ID HBG2_HUMAN STANDARD; PRT; 146 AA. AC P69892; P02096; P62027; Q68NH9; Q96FH7; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 21-JUL-1986, sequence version 1. DT 02-MAY-2006, entry version 20. DE Hemoglobin gamma-2 subunit (Hemoglobin gamma-2 chain) (Gamma-2-globin) DE (Hemoglobin gamma-G chain) (Hb F Ggamma). GN Name=HBG2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP PROTEIN SEQUENCE. RX PubMed=14087393; RA Schroeder W.A., Shelton J.R., Shelton J.B., Cormick J., Jones R.T.; RT "The amino acid sequence of the gamma chain of human fetal RT hemoglobin."; RL Biochemistry 2:992-1008(1963). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=81064665; PubMed=7438203; DOI=10.1016/0092-8674(80)90426-2; RA Slightom J.L., Blechl A.E., Smithies O.; RT "Human fetal G gamma- and A gamma-globin genes: complete nucleotide RT sequences suggest that DNA can be exchanged between these duplicated RT genes."; RL Cell 21:627-638(1980). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=81237783; PubMed=7250702; DOI=10.1016/0378-1119(80)90103-1; RA Cavallesco C., Forget B.G., Deriel J.K., Wilson L.B., Wilson J.T., RA Weissman S.M.; RT "Nucleotide sequence of human G gamma globin messenger RNA."; RL Gene 12:215-221(1980). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT M-CIRCLEVILLE LEU-63. RA Kutlar F., Shell R.D., Elam D., Holley L., Nechtman J., Kutlar A.; RT "A new G-gamma globin chain variant (His63Leu), hemoglobin M- RT Circleville found in a Caucasian family."; RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Lung, and Placenta; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [6] RP NUCLEOTIDE SEQUENCE [MRNA] OF 121-146. RX MEDLINE=85205333; PubMed=2581851; DOI=10.1016/0378-1119(85)90093-9; RA Lang K.M., Spritz R.A.; RT "Cloning specific complete polyadenylylated 3'-terminal cDNA RT segments."; RL Gene 33:191-196(1985). RN [7] RP X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF HETERODIMER WITH ALPHA CHAIN. RX MEDLINE=77230464; PubMed=881729; RA Frier J.A., Perutz M.F.; RT "Structure of human foetal deoxyhaemoglobin."; RL J. Mol. Biol. 112:97-112(1977). RN [8] RP ACETYLATION. RX MEDLINE=71166470; PubMed=5554303; RA Stegink L.D., Meyer P.D., Brummel M.C.; RT "Human fetal hemoglobin F 1. Acetylation status."; RL J. Biol. Chem. 246:3001-3007(1971). RN [9] RP VARIANT ALBAICIN GLU-8, AND ALBAICIN GLN-8. RX PubMed=2435680; RA de Pablos J.M., Wilson J.B., Kutlar A., Chen S.S., Huisman T.H.; RT "Hb F-Albaicin or G gamma 8(A5)Lys-->Glu or Gln."; RL Hemoglobin 10:655-659(1986). RN [10] RP VARIANT AUCKLAND ASN-7. RX MEDLINE=75036118; PubMed=4429671; RA Carrell R.W., Owen M.C., Anderson R., Berry E.; RT "Haemoglobin F auckland G gamma 7 Asp leads to Asn: further evidence RT for multiple genes for the gamma chain."; RL Biochim. Biophys. Acta 365:323-327(1974). RN [11] RP VARIANT AUSTELL LYS-40. RX MEDLINE=89007589; PubMed=2459083; RA Kutlar A., Kutlar F., Wilson J.B., Webber B.B., Hu H., Huisman T.H.J.; RT "Hb F-Austell or alpha 2G gamma (2)40(C6)Arg-->Lys."; RL Hemoglobin 12:409-411(1988). RN [12] RP VARIANT BROOKLYN GLN-66. RX MEDLINE=91107346; PubMed=1703138; RA Plaseska D., Li H.-J., Wilson J.B., Kutlar F., Kutlar A., RA Huisman T.H.J., Kulpa J.; RT "Hb F-Brooklyn or alpha 2G gamma 2(66)(E10)Lys-->Gln."; RL Hemoglobin 14:213-216(1990). RN [13] RP VARIANT CALABRIA LEU-118. RX MEDLINE=20185189; PubMed=10722114; RA Manca L., Cherchi L., De Rosa M.C., Giardina B., Masala B.; RT "A new, electrophoretically silent, fetal hemoglobin variant: Hb F- RT Calabria Ggamma118(GH1)Phe-->Leu."; RL Hemoglobin 24:37-44(2000). RN [14] RP VARIANT CALTECH GLN-120. RX MEDLINE=83135042; PubMed=6186635; RA Shelton J.B., Shelton J.R., Espinueva Z., Huynh V., Schroeder W.A., RA Powars D.; RT "Hemoglobin F-Caltech: alpha 2 G gamma 2 120Lys replaced by Gln."; RL Hemoglobin 6:577-592(1982). RN [15] RP VARIANT CATALONIA ARG-15. RX MEDLINE=91177713; PubMed=1706691; RA Plaseska D., Wilson J.B., Kutlar F., Font L., Baiget M., RA Huisman T.H.J.; RT "Hb F-Catalonia or alpha 2G gamma(2)15(A12)Trp-->Arg."; RL Hemoglobin 14:511-516(1990). RN [16] RP VARIANT CHARLOTTE THR-75. RX MEDLINE=91331856; PubMed=1714434; RA Plaseska D., Kutlar F., Wilson J.B., Fei Y.J., Huisman T.H.J.; RT "Hb F-Charlotte, an A gamma variant with a threonine residue in RT position gamma 75 and a glycine residue in position gamma 136."; RL Hemoglobin 14:617-625(1990). RN [17] RP VARIANT CINCINNATI SER-41. RX PubMed=7741137; RA Kohli-Kumar M., Zwerdling T., Rucknagel D.L.; RT "Hemoglobin F-Cincinnati, alpha 2G gamma 2 41(C7) Phe-->Ser in a RT newborn with cyanosis."; RL Am. J. Hematol. 49:43-47(1995). RN [18] RP VARIANTS CLAMART ASN-17 AND OULED RABAH LYS-19. RX PubMed=10722115; RA Wajcman H., Borensztajn K., Riou J., Prome D., Hurtrel D., RA Bardakdjian J., Lena-Russo D., Amouroux I., Ducrocq R.; RT "Two new Ggamma chain variants: Hb F-clamart [gamma17(A14)Lys-->Asn] RT and Hb F-Ouled Rabah [gamma19(B1)Asn-->Lys]."; RL Hemoglobin 24:45-52(2000). RN [19] RP VARIANT CLARKE ASN-65. RX PubMed=2442123; RA Kutlar A., Kutlar F., Wilson J.B., Webber B.B., Gonzalez Redondo J.M., RA Huisman T.H.; RT "Hb F-Clarke or alpha 2G gamma 2(65)(E9)Lys-->Asn."; RL Hemoglobin 11:185-188(1987). RN [20] RP VARIANT COLUMBUS-GA ASN-94. RX MEDLINE=83135043; PubMed=6186636; RA Nakatsuji T., Lam H., Wilson J.B., Webber B.B., Huisman T.H.J.; RT "Hb F-Columbus-Ga or alpha 2 G gamma 2 94(FGl) Asp replaced by Asn."; RL Hemoglobin 6:593-598(1982). RN [21] RP VARIANT COSENZA GLU-25. RX MEDLINE=92267854; PubMed=1726095; RA Qualtieri A., Crescibene L., Bagala A., de Marco E.V., Bria M., RA Brancati C.; RT "Hb F-Cosenza or G gamma 25(B7)Gly-->Glu: a new fast-moving fetal RT hemoglobin variant."; RL Hemoglobin 15:509-515(1991). RN [22] RP VARIANT EMIRATES GLU-59, AND SACROMONTE GLN-59. RX PubMed=7558873; RA Abbes S., Fitzgerald P.A., Varady E., Girot R., Pic P., Blouquit Y., RA Ducrocq R., Drupt F., Wajcman H.; RT "Two fetal hemoglobin variants affecting the same residue: Hb F- RT Emirates [G gamma 59(E3)Lys-->Glu] and Hb F-Sacromonte [G gamma RT 59(E3)Lys-->Gln]."; RL Hemoglobin 19:173-182(1995). RN [23] RP VARIANT FORT RIPLEY TYR-92. RX MEDLINE=89239847; PubMed=2470017; RA Priest J.R., Watterson J., Jones R.T., Faassen A.E., Hedlund B.E.; RT "Mutant fetal hemoglobin causing cyanosis in a newborn."; RL Pediatrics 83:734-736(1989). RN [24] RP VARIANTS FUCHU GLN-21 AND MINOO ARG-72. RX PubMed=3120456; RA Hayashi A., Wada Y., Matsuo T., Katakuse I., Matsuda H.; RT "Neonatal screening and mass-spectrometric analysis of hemoglobin RT variants in Japan."; RL Acta Haematol. 78:114-118(1987). RN [25] RP VARIANT GRANADA VAL-22. RX MEDLINE=89007588; PubMed=2459082; RA de Pablos J.M., Clegg J.B.; RT "Hb F-Granada or alpha 2G gamma (2)22(B4)Asp-->Val: a new human fetal RT hemoglobin variant."; RL Hemoglobin 12:405-407(1988). RN [26] RP VARIANT KENNESTONE ARG-77. RX MEDLINE=83265056; PubMed=6192110; RA Nakatsuji T., Lam H., Huisman T.H.J.; RT "Hb F-Kennestone or alpha 2G gamma 2 (EF1)77 His leads to Arg observed RT in a Caucasian baby."; RL Hemoglobin 7:267-270(1983). RN [27] RP VARIANT KINGSTON ARG-55. RX MEDLINE=83132267; PubMed=6186522; DOI=10.1016/0014-5793(82)81307-0; RA Serjeant G.R., Serjeant B.E., Lehmann H., Dukes M., Robb L.; RT "Hb F Kingston (G gamma 55 [D6] Met leads to Arg)."; RL FEBS Lett. 150:77-80(1982). RN [28] RP VARIANT LA GRANGE LYS-101. RX MEDLINE=85000557; PubMed=6206897; DOI=10.1016/0167-4838(84)90208-5; RA Nakatsuji T., Shimizu K., Huisman T.H.J.; RT "Hb F-La Grange or alpha 2 gamma 2 101(G3)Glu-->Lys; 75Ile; 136Gly: a RT high oxygen affinity fetal hemoglobin variant observed in a Caucasian RT newborn."; RL Biochim. Biophys. Acta 789:224-228(1984). RN [29] RP VARIANT LESVOS THR-75. RX MEDLINE=96163507; PubMed=8566966; RA Papadakis M.N., Patrinos G.P., Drakoulakou O., Loutradi-Anagnostou A.; RT "HbF-Lesvos: an HbF variant due to a novel G gamma mutation (G gamma RT 75 ATA-->ACA) detected in a Greek family."; RL Hum. Genet. 97:260-262(1996). RN [30] RP VARIANT LODZ ARG-44. RX MEDLINE=83049121; PubMed=6814491; DOI=10.1016/0167-4838(82)90353-3; RA Honig G.R., Koshy M., Schroeder W.A., Shelton J.B., Shelton J.R.; RT "Hemoglobin F Lodz (G gamma I 44 Ser replaced by Arg). A newly RT identified variant from an American infant of Polish descent."; RL Biochim. Biophys. Acta 707:213-216(1982). RN [31] RP VARIANT MACEDONIA-II ASN-104. RX PubMed=7713741; RA Plaseska D., Panovska-Popovska S., Lazarevski M., Efremov G.D.; RT "Hb F-Macedonia-II [G gamma 104(G6)Lys-->Asn]: a new gamma chain RT variant."; RL Hemoglobin 18:373-382(1994). RN [32] RP VARIANT MALAYSIA CYS-1. RX MEDLINE=74258593; PubMed=4837284; RA Lie-Injo L.E., Kamuzora H., Lehmann H.; RT "Haemoglobin F Malaysia: alpha 2, gamma 2 1(NA1) glycine-->cysteine; RT 136 glycine."; RL J. Med. Genet. 11:25-30(1974). RN [33] RP VARIANT MALTA-1 ARG-117. RX PubMed=5792729; RA Cauchi M.N., Clegg J.B., Weatherall D.J.; RT "Haemoglobin F(Malta): a new foetal haemoglobin variant with a high RT incidence in Maltese infants."; RL Nature 223:311-313(1969). RN [34] RP VARIANT MEINOHAMA GLY-5. RX MEDLINE=82097665; PubMed=6172403; RA Ohta Y., Saito S., Fujita S., Wilson J.B., Lam H., Huisman T.H.J.; RT "Hb F-Meinohama or alpha 2 gamma 2 (5 Glu replaced by Gly; 75 Ile; 136 RT Gly)."; RL Hemoglobin 5:565-570(1981). RN [35] RP VARIANTS MELBOURNE ARG-16 AND CARLTON LYS-121. RX PubMed=836882; DOI=10.1016/0005-2795(77)90020-4; RA Brennan S.O., Smith M.B., Carrell R.W.; RT "Haemoglobin F Melbourne Ggamma 16 Gly leads to Arg and haemoglobin F RT carlton Ggamma 121 Glu leads to Lys. Further evidence for varied RT activity of gamma-chain genes."; RL Biochim. Biophys. Acta 490:452-455(1977). RN [36] RP VARIANT OAKLAND LYS-26. RX MEDLINE=87307476; PubMed=2442122; RA Kleman K., Lubin B., Wilson J.B., Kutlar A., Webber B.B., RA Huisman T.H.J.; RT "Hb F-Oakland or alpha 2G gamma I2(26)(B8)Glu-->Lys."; RL Hemoglobin 11:181-183(1987). RN [37] RP VARIANT ONODA TYR-146. RX MEDLINE=91107347; PubMed=1703139; RA Harano T., Harano K., Doi K., Ueda S., Imai K., Ohba Y., Kutlar F., RA Huisman T.H.J.; RT "Hb F-Onoda or alpha 2G gamma 2(146)(HC3)His-->Tyr, a newly discovered RT fetal hemoglobin variant in a Japanese newborn."; RL Hemoglobin 14:217-222(1990). RN [38] RP VARIANT OSAKA TYR-63. RX MEDLINE=90236758; PubMed=2483933; RA Glader B.E., Zwerdling D., Kutlar F., Kutlar A., Wilson J.B., RA Huisman T.H.J.; RT "Hb F-M-Osaka or alpha 2G gamma 2(63)(E7)His-->Tyr in a Caucasian male RT infant."; RL Hemoglobin 13:769-773(1989). RN [39] RP VARIANT POOLE GLY-130. RX MEDLINE=75151976; PubMed=1127124; RA Lee-Potter J.P., Deacon-Smith R.A., Simpkiss M.J., Kamuzora H., RA Lehmann H.; RT "A new cause of haemolytic anaemia in the newborn. A description of an RT unstable fetal haemoglobin: F Poole, alpha2-G-gamma2 130 trptophan RT yeilds glycine."; RL J. Clin. Pathol. 28:317-320(1975). RN [40] RP VARIANT PORT-ROYAL ALA-125. RX MEDLINE=74287006; PubMed=4846278; RA Brimhall B., Vedvick T.S., Jones R.T., Ahern E., Palomino E., RA Ahern V.; RT "Haemoglobin F Port Royal (alpha2G gamma2 125 Glu leads to Ala)."; RL Br. J. Haematol. 27:313-318(1974). RN [41] RP VARIANT SASKATOON LYS-21. RX PubMed=8144355; RA Pobedimskaya D.D., Molchanova T.P., Huisman T.H., Harding S.R., RA Bakanec R.; RT "Hb F-Saskatoon or alpha 2G gamma (2)21(B3)Glu-->Lys observed in a RT North American indian newborn."; RL Hemoglobin 17:547-549(1993). RN [42] RP VARIANT SHANGHAI ARG-66. RX PubMed=2579547; RA Zeng Y.T., Huang S.Z., Nakatsuji T., Huisman T.H.; RT "-G gamma A gamma-Thalassemia and gamma-chain variants in Chinese RT newborn babies."; RL Am. J. Hematol. 18:235-242(1985). RN [43] RP VARIANT TOKYO ILE-34. RX MEDLINE=85206961; PubMed=2581919; RA Chen S.S., Wilson J.B., Webber B.B., Huisman T.H.J., Miwa S., RA Amenomori Y.; RT "Hb F-Tokyo or alpha 2G gamma 2 34(B16)Val-->Ile, a silent gamma chain RT variant detected by reverse phase high performance liquid RT chromatography."; RL Hemoglobin 9:25-32(1985). RN [44] RP VARIANT URUMQI GLY-22. RX PubMed=2420748; RA Hu H.Y., Ma M.S.; RT "Hb F-Urumqi G gamma I22(B4)Asp-->Gly: a new fetal hemoglobin variant RT found in a Uygur baby."; RL Hemoglobin 10:15-20(1986). RN [45] RP VARIANT VELETA GLY-22. RX PubMed=8718700; RA de Pablos Gallego J.M., Gu L.H., Leonova J.Y., Huisman T.H.; RT "Hb F-Veleta or alpha 2 G gamma(2)40(C6)Arg-->Gly."; RL Hemoglobin 19:407-411(1995). RN [46] RP VARIANT WAYNESBORO THR-75. RX PubMed=8718701; RA Gu L.H., Oner C., Huisman T.H.; RT "The G gamma T chain (G gamma 75 Thr; 136 Gly) in Hb F-Charlotte is RT the product of an A gamma gene with a limited gene conversion and that RT in Hb F-Waynesboro of a mutated G gamma gene."; RL Hemoglobin 19:413-418(1995). CC -!- FUNCTION: Gamma chains make up the fetal hemoglobin F, in CC combination with alpha chains. CC -!- SUBUNIT: Heterotetramer of two alpha chains and two gamma chains CC in fetal hemoglobin (Hb F). CC -!- TISSUE SPECIFICITY: Red blood cells. CC -!- DEVELOPMENTAL STAGE: Expressed until four or five weeks after CC birth. CC -!- PTM: Acetylation of Gly-1 converts Hb F to the minor Hb F1. CC -!- DISEASE: Some gamma variants can cause severe jaundice and CC cyanosis in premature and new born babies. CC -!- SIMILARITY: Belongs to the globin family. CC -!- DATABASE: NAME=Hb variant; NOTE=Human hemoglobin variants; CC WWW="http://globin.cse.psu.edu/globin/html/huisman/variants/". CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; M91036; AAB59428.1; -; Genomic_DNA. DR EMBL; M91037; AAA58492.1; -; Genomic_DNA. DR EMBL; U01317; AAA16331.1; -; Genomic_DNA. DR EMBL; V00515; CAA23773.1; -; Genomic_DNA. DR EMBL; AY662983; AAT98611.1; -; Genomic_DNA. DR EMBL; BC029387; AAH29387.1; -; mRNA. DR EMBL; M11427; AAA35957.1; -; mRNA. DR PIR; A90803; HGHUA. DR UniGene; Hs.302145; -. DR UniGene; Hs.567283; -. DR PDB; 1FDH; X-ray; -. DR Ensembl; ENSG00000197458; Homo sapiens. DR HGNC; HGNC:4832; HBG2. DR MIM; 142250; gene. DR LinkHub; P69892; -. DR InterPro; IPR002337; Beta_haem. DR InterPro; IPR000971; Globin. DR InterPro; IPR009050; Globin_like. DR InterPro; IPR012292; Globin_related. DR Pfam; PF00042; Globin; 1. DR PRINTS; PR00814; BETAHAEM. DR PROSITE; PS01033; GLOBIN; 1. KW 3D-structure; Acetylation; Direct protein sequencing; KW Disease mutation; Heme; Iron; Metal-binding; Oxygen transport; KW Polymorphism; Transport. FT INIT_MET 0 0 FT CHAIN 1 146 Hemoglobin gamma-2 subunit. FT /FTId=PRO_0000053254. FT METAL 63 63 Iron (heme distal ligand). FT METAL 92 92 Iron (heme proximal ligand). FT MOD_RES 1 1 N-acetylglycine (in form Hb F1). FT VARIANT 1 1 G -> C (in Malaysia). FT /FTId=VAR_003123. FT VARIANT 5 5 E -> G (in Meinohama). FT /FTId=VAR_003126. FT VARIANT 7 7 D -> N (in Auckland). FT /FTId=VAR_003129. FT VARIANT 8 8 K -> E (in Albaicin). FT /FTId=VAR_020643. FT VARIANT 8 8 K -> Q (in Albaicin). FT /FTId=VAR_020644. FT VARIANT 12 12 T -> R (in Heather). FT /FTId=VAR_020645. FT VARIANT 15 15 W -> R (in Catalonia). FT /FTId=VAR_003131. FT VARIANT 16 16 G -> R (in Melbourne). FT /FTId=VAR_003132. FT VARIANT 17 17 K -> N (in Clamart). FT /FTId=VAR_020646. FT VARIANT 19 19 N -> K (in Ouled Rabah). FT /FTId=VAR_020647. FT VARIANT 21 21 E -> K (in Saskatoon). FT /FTId=VAR_003133. FT VARIANT 21 21 E -> Q (in Fuchu). FT /FTId=VAR_003134. FT VARIANT 22 22 D -> G (in Urumqi). FT /FTId=VAR_020648. FT VARIANT 22 22 D -> V (in Granada). FT /FTId=VAR_003136. FT VARIANT 25 25 G -> E (in Cosenza). FT /FTId=VAR_003137. FT VARIANT 26 26 E -> K (in Oakland). FT /FTId=VAR_003139. FT VARIANT 34 34 V -> I (in Tokyo). FT /FTId=VAR_003140. FT VARIANT 40 40 R -> G (in Veleta). FT /FTId=VAR_003144. FT VARIANT 40 40 R -> K (in Austell). FT /FTId=VAR_020649. FT VARIANT 41 41 F -> S (in Cincinnati). FT /FTId=VAR_003146. FT VARIANT 44 44 S -> R (in Lodz). FT /FTId=VAR_003148. FT VARIANT 55 55 M -> R (in Kingston). FT /FTId=VAR_003150. FT VARIANT 59 59 K -> E (in Emirates). FT /FTId=VAR_003151. FT VARIANT 59 59 K -> Q (in Sacromonte). FT /FTId=VAR_003152. FT VARIANT 63 63 H -> L (in M-Circleville). FT /FTId=VAR_025336. FT VARIANT 63 63 H -> Y (in Osaka; it causes cyanosis). FT /FTId=VAR_003154. FT VARIANT 65 65 K -> N (in Clarke). FT /FTId=VAR_003155. FT VARIANT 66 66 K -> Q (in Brooklyn). FT /FTId=VAR_003157. FT VARIANT 66 66 K -> R (in Shanghai). FT /FTId=VAR_003156. FT VARIANT 72 72 G -> R (in Minoo). FT /FTId=VAR_020650. FT VARIANT 75 75 I -> T (in LesVos/Waynesboro/Charlotte). FT /FTId=VAR_020651. FT VARIANT 77 77 H -> R (in Kennestone). FT /FTId=VAR_003162. FT VARIANT 80 80 D -> N (in Marietta). FT /FTId=VAR_020652. FT VARIANT 92 92 H -> Y (in Fort Ripley; it causes FT cyanosis). FT /FTId=VAR_003166. FT VARIANT 94 94 D -> N (in Columbus-Ga). FT /FTId=VAR_003167. FT VARIANT 101 101 E -> K (in La Grange). FT /FTId=VAR_003169. FT VARIANT 104 104 K -> N (in Macedonia-II). FT /FTId=VAR_003170. FT VARIANT 117 117 H -> R (in Malta-1). FT /FTId=VAR_003171. FT VARIANT 118 118 F -> L (in Calabria). FT /FTId=VAR_015740. FT VARIANT 120 120 K -> Q (in Caltech). FT /FTId=VAR_003172. FT VARIANT 121 121 E -> K (in Carlton). FT /FTId=VAR_020653. FT VARIANT 125 125 E -> A (in Port-Royal). FT /FTId=VAR_003174. FT VARIANT 130 130 W -> G (in Poole; unstable). FT /FTId=VAR_003176. FT VARIANT 146 146 H -> Y (in Onoda; O(2) affinity up). FT /FTId=VAR_003179. FT HELIX 5 16 FT TURN 17 17 FT HELIX 20 34 FT HELIX 36 45 FT HELIX 51 56 FT HELIX 58 74 FT HELIX 75 80 FT HELIX 81 84 FT TURN 85 85 FT HELIX 86 93 FT TURN 94 96 FT HELIX 100 118 FT HELIX 119 121 FT HELIX 124 141 FT TURN 142 142 FT HELIX 143 146 SQ SEQUENCE 146 AA; 15995 MW; C6196E21C8F05DDE CRC64; GHFTEEDKAT ITSLWGKVNV EDAGGETLGR LLVVYPWTQR FFDSFGNLSS ASAIMGNPKV KAHGKKVLTS LGDAIKHLDD LKGTFAQLSE LHCDKLHVDP ENFKLLGNVL VTVLAIHFGK EFTPEVQASW QKMVTGVASA LSSRYH //