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Работа с базой данных GO
Описание функции белка с помощью аннотации Gene Ontology
| Онтология GO (название словаря) | Количество разных ассоциированных терминов GO | Функция белка (краткое описание, близкое к тексту определения термина(ов) GO |
|
|---|---|---|---|
| Где? | - | - | - |
| Зачем, для чего? | P | 3 | Процесс биосинтеза лизина через диаминопимелат |
| Молекулярный механизм? | F | 6 | диаминопимелат декарбоксилазная активность |
| Специфичность? | словарь отсутствует | 0 | термины отсутствуют |
Описание терминов GO
| GO ID выбранного термина | Список синонимов | Список ближайших дочерних терминов GO с указанием типа связи | Список ближайших родительских терминов GO с указанием типа связи |
|---|---|---|---|
| GO:0009089 | diaminopimelate pathway diaminopimelic acid pathway lysine anabolism via diaminopimelate lysine biosynthesis via diaminopimelic acid lysine biosynthetic process via diaminopimelic acid lysine formation via diaminopimelate lysine synthesis via diaminopimelate |
GO:0019877 : diaminopimelate biosynthetic process (part of) GO:0033360 : lysine biosynthetic process via diaminopimelate and L-2-acetamido-6-oxoheptanedioate (is a) GO:0033359 : lysine biosynthetic process via diaminopimelate and N-succinyl-2-amino-6-ketopimelate (is a) GO:0033361 : lysine biosynthetic process via diaminopimelate, dehydrogenase pathway (is a) GO:0033362 : lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway (is a) | GO:0009085 : lysine biosynthetic process (is a) GO:0009085 : lysine biosynthetic process (is a) |
| GO:0016831 | decarboxylase activity | GO:0047432 : 2,2-dialkylglycine decarboxylase (pyruvate) activity GO:0034879 : 2,3,6-trihydroxyisonicotinate decarboxylase activity GO:0018790 : 2,3-dihydroxybenzoate decarboxylase activity GO:0034853 : 2,4,4-trimethyl-3-oxopentanoate decarboxylase activity GO:0018802 : 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase activity GO:0018795 : 2-hydroxy-2-methyl-1,3-dicarbonate decarboxylase activity GO:0018791 : 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate decarboxylase activity GO:0018794 : 2-hydroxyisobutyrate decarboxylase activity GO:0034524 : 2-hydroxyisophthalate decarboxylase activity GO:0051997 : 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity GO:0008683 : 2-oxoglutarate decarboxylase activity GO:0034913 : 3,4-dihydroxyphthalate 2-decarboxylase activity GO:0047556 : 3,4-dihydroxyphthalate decarboxylase activity GO:0018793 : 3,5-dibromo-4-hydroxybenzoate decarboxylase activity GO:0033982 : 3-dehydro-L-gulonate-6-phosphate decarboxylase activity GO:0047431 : 3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase activity GO:0008694 : 3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity GO:0050410 : 3-oxolaurate decarboxylase activity GO:0034854 : 4,4-dimethyl-3-oxopentanoate decarboxylase activity GO:0018796 : 4,5-dihydroxyphthalate decarboxylase activity GO:0018803 : 4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase activity GO:0047575 : 4-carboxymuconolactone decarboxylase activity GO:0018799 : 4-hydroxybenzoate decarboxylase activity GO:0043722 : 4-hydroxyphenylacetate decarboxylase activity GO:0050546 : 4-hydroxyphenylpyruvate decarboxylase activity GO:0047437 : 4-oxalocrotonate decarboxylase activity GO:0043727 : 5-amino-4-imidazole carboxylate lyase activity GO:0047435 : 5-guanidino-2-oxopentanoate decarboxylase activity GO:0018800 : 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase activity GO:0047596 : 6-methylsalicylate decarboxylase activity GO:0047602 : acetoacetate decarboxylase activity GO:0047605 : acetolactate decarboxylase activity GO:0050476 : acetylenedicarboxylate decarboxylase activity GO:0047613 : aconitate decarboxylase activity GO:0004014 : adenosylmethionine decarboxylase activity GO:0047662 : aminobenzoate decarboxylase activity GO:0001760 : aminocarboxymuconate-semialdehyde decarboxylase activity GO:0008792 : arginine decarboxylase activity GO:0004058 : aromatic-L-amino-acid decarboxylase activity GO:0047436 : arylmalonate decarboxylase activity GO:0004068 : aspartate 1-decarboxylase activity GO:0047688 : aspartate 4-decarboxylase activity GO:0050695 : benzoylformate decarboxylase activity GO:0018792 : bis(4-chlorophenyl)acetate decarboxylase activity GO:0047433 : branched-chain-2-oxoacid decarboxylase activity GO:0047729 : carnitine decarboxylase activity GO:0033981 : D-dopachrome decarboxylase activity GO:0047842 : dehydro-L-gulonate decarboxylase activity GO:0033983 : diaminobutyrate decarboxylase activity GO:0008836 : diaminopimelate decarboxylase activity GO:0010298 : dihydrocamalexic acid decarboxylase activity GO:0047858 : dihydroxyfumarate decarboxylase activity GO:0034782 : dimethylmalonate decarboxylase activity GO:0004163 : diphosphomevalonate decarboxylase activity GO:0018798 : gallate decarboxylase activity GO:0008488 : gamma-glutamyl carboxylase activity GO:0047923 : gentisate decarboxylase activity GO:0018801 : glutaconyl-CoA decarboxylase activity GO:0004351 : glutamate decarboxylase activity GO:0004398 : histidine decarboxylase activity GO:0047990 : hydroxyglutamate decarboxylase activity GO:0047997 : hydroxypyruvate decarboxylase activity GO:0004425 : indole-3-glycerol-phosphate synthase activity GO:0047434 : indolepyruvate decarboxylase activity GO:0008923 : lysine decarboxylase activity GO:0034952 : malonate semialdehyde decarboxylase activity GO:0050080 : malonyl-CoA decarboxylase activity GO:0050095 : methionine decarboxylase activity GO:0004492 : methylmalonyl-CoA decarboxylase activity GO:0050150 : o-pyrocatechuate decarboxylase activity GO:0004586 : ornithine decarboxylase activity GO:0004590 : orotidine-5'-phosphate decarboxylase activity GO:0050159 : orsellinate decarboxylase activity GO:0046564 : oxalate decarboxylase activity GO:0008948 : oxaloacetate decarboxylase activity GO:0008949 : oxalyl-CoA decarboxylase activity GO:0050167 : pantothenoylcysteine decarboxylase activity GO:0034923 : phenanthrene-4,5-dicarboxylate decarboxylase activity GO:0050174 : phenylalanine decarboxylase activity GO:0050177 : phenylpyruvate decarboxylase activity GO:0004609 : phosphatidylserine decarboxylase activity GO:0004611 : phosphoenolpyruvate carboxykinase activity GO:0033980 : phosphonopyruvate decarboxylase activity GO:0004633 : phosphopantothenoylcysteine decarboxylase activity GO:0004638 : phosphoribosylaminoimidazole carboxylase activity GO:0050223 : protocatechuate decarboxylase activity GO:0034941 : pyrrole-2-carboxylate decarboxylase activity GO:0004737 : pyruvate decarboxylase activity GO:0016984 : ribulose-bisphosphate carboxylase activity GO:0050296 : stipitatonate decarboxylase activity GO:0004782 : sulfinoalanine decarboxylase activity GO:0050545 : sulfopyruvate decarboxylase activity GO:0050319 : tartrate decarboxylase activity GO:0009028 : tartronate-semialdehyde synthase activity GO:0034947 : terephthalate decarboxylase activity GO:0048472 : threonine-phosphate decarboxylase activity GO:0004837 : tyrosine decarboxylase activity GO:0050374 : UDP-galacturonate decarboxylase activity GO:0048040 : UDP-glucuronate decarboxylase activity GO:0050382 : uracil-5-carboxylate decarboxylase activity GO:0004853 : uroporphyrinogen decarboxylase activity GO:0050390 : valine decarboxylase activity | GO:0016830 : carbon-carbon lyase activity (is a) |
Оценка качества функциональной аннотации белков в UniProt
Cavia porcellus(Морская свинка,Guinea pig): Taxonomy ID: 10141; Ранг: Вид;| Количество в UniProt | Количество в UniRef100 | |
|---|---|---|
| Существование белка доказано экспериментально | 69 | 122 |
| Известны только соответствующие транскрипты | 537 | 575 |
| Гипотетический белок, предсказан по гомологии | 103 | 169 |
| Иные предсказанные гипотетические белки | 69 | 69 |
Использование GO для работы с массовыми данными
Получение выборки последовательностей белков с заданной функцией
Функция: Репликация ДНК(DNA replication)GOID: GO:0006260; По запросу [uniprot-Spicies:cavia]&[uniprot-DbXref:GO:0006260] найдено 0 результатов.
Определение главной функции в большом списке белков
| GO | Онтология | pvalue\количество | значение |
| GO:0009067 | P | 4.5e-11/9 | aspartate family amino acid anabolism |
| GO:0009066 | P | 5.43e-11/9 | aspartate family amino acid metabolism |
| GO:0006553 | P | 5.43e-11/7 | lysine metabolism |
| GO:0009085 | P | GO:0009085/7 | lysine anabolism |
| GO:0046451 | P | 2.63e-09/6 | diaminopimelate metabolism |
| GO:0009089 | P | 2.63e-09/6 | diaminopimelate pathway |
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