Поисковые системы

Учебный сайт Люды Андреевой

Краткое сравнение поисковых систем SRS, MRS и UniProt

Поисковые системы сравнивались по представлениям в них записи SwissProt а также по удобству поиска.

Поиск SRS. Содержит максимально много ссылок. Удобный многофакторный поиск. Информация на странице разбита по темам, к каждой из которых вверху страницы есть ссылка. Красочное поле features, содержащее схему расположения особенностей белка со шкалой длины. Большой выбор представления аминокислотной последовательности.
Посмотрите сами
Поиск MRs. В описании белка используются только слова из документа, без особых пояснений и расшифровок. Неудачная строка поиска: на мой запрос «р13001» - Ac моего белка было получено 16 результатов, в числе которых – белки BIOH др организмов. Неудачно поле Features, поскольку при попытке прочитать запись целиком уезжают заголовки и невозможно увидеть описание вторичной структуры целиком. Качественно выполнено описание статей, невыразительная последовательность.
Посмотрите сами
Поиск UniProt. Удобный поиск, большое количество вариантов оформления страницы. Оглавление сверху для перемещения по странице. Большое количество схем, ссылок (в т.ч. и на 3д структуру). Удобное представление последовательности с нумерацией десятков аминокислот. Не хватает ссылок на статьи.
Посмотрите сами

Поиск по таксономии в SRS

В поисковой системе SRS для удобства существует страница с описанием поля "Taxonomy" записи в банке SwissProt. С помощью неё можно находить различные данные, находящиеся в соответствующем поле записи, причем поиск может проводиться как с использованием целого слова, так и его части. С помощью этой страницы удалось установить:

На "gam" начинаются таксоны gambusia, gammaherpesvirinae, gammapapillomavirus, gammaproteobacteria, gammaretrovirus, gammaridea.
Английский эквивалент таксона "гамма-протеобактерия" звучит как gammaproteobacteria.
В банке SwissProt находится 83513 записей с описанием белков гамма-протеобактерий.

Поиск в SRS белков с функцией, сходной с BIOH_ECOLI

Формулировка функции белка Строка запроса Количество найденных документов

Carboxylesterase bioH ((([swissprot-Description:Carboxylesterase*] & [swissprot-Description:bioH*]) | [swissprot-Description:Carboxylesterase bioH*]) & [swissprot-Taxonomy:gammaproteobacteria*]) 55

Biotin synthesis protein bioH ((((([swissprot-Description:Biotin*] & [swissprot-Description:synthesis*]) & [swissprot-Description:protein*]) & [swissprot-Description:bioH*]) | [swissprot-Description:Biotin synthesis protein bioH*]) & [swissprot-Taxonomy:gammaproteobacteria*]) 55

Carboxylesterase ([swissprot-Description:Carboxylesterase*] & [swissprot-Taxonomy:gammaproteobacteria*]) 57

Biotin synthesis protein (((([swissprot-Description:Biotin*] & [swissprot-Description:synthesis*]) & [swissprot-Description:protein*]) | [swissprot-Description:Biotin synthesis protein*]) & [swissprot-Taxonomy:gammaproteobacteria*]) 60

Сarboxylesterase activity with a preference for short chain fatty acid esters 0

Carboxylesterase, thioesterase ((([swissprot-Comment:thioesterase*] > parent ) & ([swissprot-Comment:carboxylesterase*] > parent )) & [swissprot-Taxonomy:gammaproteobacteria*]) 55

A complex with CoA, carboxylesterase carboxylesterase 0

A precursor in biotin biosynthesis,carboxylesterase 0

Аминокислотные последователности

В предыдущем пункте шёл поиск белков с похожей на BIOH_ECOLI функцией. Воспользовавшись результатами первого из приведённых выше поиска, были найдены аминокислотные последовательности этих белков, которые представлены ниже.

>sp|Q89A54|BIOH_BUCBP Carboxylesterase bioH;
MNKKLHWKSLGTGTTNLILIHGWGVNSKIWSILVQSQLYQHFKLHFVDLPGFGHSNQLLP
MTLNDTAELLSVYIPKNSILLGWSMGGLIASKIALNYPQKIKGIISVCSSPCFIVRPNWP
GIPKKIFLKFYNKLNINFDRTISEFITLQSHNTNYLEIKNLKQQILSQPYPTIYTLKKNL
ETIFKTDLRTKIKKLKIPMLRIYGSLDTFVPKKIREILDILWPKTKSITIAHASHIPFVS
HQKEFYESIINFKNYLNTLKITCQK
>sp|A8AQW5|BIOH_CITK8 Carboxylesterase bioH;
MNDIWWQTEGQGNCHLVLLHGWGLNAEVWNCIREELSAHFTLHLVDLPGFGRSQGFGAMS
LEQMAKHVLKQAPDKAVWLGWSLGGLVASQVALTHPERVQALVTVASSPCFSAREAWPGI
KPDILAGFQQQLSEDFQRTVERFLALQTLGTETARQDARTLKSAVLALPMPEVAVLNGGL
EILKTADLREPLKSLTMPFLRLYGYLDGLVPRKVVPMLDAAWPESESQVFAKAAHAPFIS
HPGEFCQALMALKQKI
>sp|A7ZSU1|BIOH_ECO24 Carboxylesterase bioH;
MNNIWWQTKGQGNVHLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSRGFGALS
LADMAEAVLQQAPDKAIWLGWSLGGLVASQIALTHPERVQALVTVASSPCFSARDEWPGI
KPDVLAGFQQQLSDDFQRTVERFLALQTMGTETARQDARALKKTVLALPMPEVDVLNGGL
EILKTVDLRQPLQNVPMPFLRLYGYLDGLVPRKVVPMLDKLWPHSESYIFAKAAHAPFIS
HPVEFCHLLVALKQRV
>sp|Q8X716|BIOH_ECO57 Carboxylesterase bioH;
MNNIWWQTKGQGNVHLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSRGFGALS
LAEMAEAVLRQAPDKAIWLGWSLGGLVASQIALTHPERVQALVTVASSPCFSARDEWPGI
KPDVLAGFQQQLSDDFQRTVERFLALQTMGTETARQDARALKKTVLALPMPEVDVLNGGL
EILKTVDLRLPLQNVPMPFLRLYGYLDGLVPRKVVPMLDKLWPHSESYIFAKAAHAPFIS
HPVEFRHVLVALKQRV
>sp|A8A5M0|BIOH_ECOHS Carboxylesterase bioH;
MNNIWWQTKGQGNVHLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSRGFGALS
LADMAEAVLQQAPDKAIWLGWSLGGLVASQIALTHPERVQALVTVASSPCFSARDEWPGI
KPDVLAGFQQQLSDDFQRTVERFLALQTMGTETARQDARALKKTVLALPMPEVDVLNGGL
EILKTVDLRQPLQNVSMPFLRLYGYLDGLVPRKVVPMLDKLWPHSESYIFAKAAHAPFIS
HPVEFCHLLVALKQRV
>sp|A1AGT6|BIOH_ECOK1 Carboxylesterase bioH;
MNNIWWQTKGQGNVHLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSRGFGALS
LADMAEAVLRQAPDKAIWLGWSLGGLVASQIALTHPERVQALVTVASSPCFSARDEWPGI
KPDVLAGFQQQLSDDFQRTVERFLALQTMGTETARQDARALKKTVLALPMPEVDVLNGGL
EILKTVDLRLPLQNVSMPFLRLYGYLDGLVPRKVVPMLDKLWPHSESYIFAKAAHAPFIS
HPVEFHHLLVALKQRV
>sp|Q0TC55|BIOH_ECOL5 Carboxylesterase bioH;
MNNIWWQTKGQGNVHLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSRGFGALS
LADMAEVVLRQAPDKAIWLGWSLGGLVASQIALTHPERVLALVTVASSPCFSARDEWPGI
KPDVLAGFQQQLSDDFQRTVERFLALQTMGTETARQDARALKKTVLALPMPEVDVLNGGL
EILKTVDLRLPLQNVSMPFLRLYGYLDGLVPRKVVPMLDKLWPHSESYIFAKAAHAPFIS
HPVEFHHLLVALKQRV
>sp|Q8FCT4|BIOH_ECOL6 Carboxylesterase bioH;
MNNIWWQTKGQGNVHLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSRGFGALS
LADMAEVVLRQAPDKAIWLGWSLGGLVASQIALTHPERVLALVTVASSPCFSARDEWPGI
KPDVLAGFQQQLSDDFQRTVERFLALQTMGTETARQDARALKKTVLALPMPEVDVLNGGL
EILKTVDLRQPLQNVPMPFLRLYGYLDGLVPRKVVPMLDKLWPHSESYIFAKAAHAPFIS
HPDEFCHLLVALKQRV
>sp|B1IP53|BIOH_ECOLC Carboxylesterase bioH;
MNNIWWQTKGQGNVHLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSRGFGALS
LADMAEAVLQQAPDKAIWLGWSLGGLVASQIALTHPERVQALVTVASSPCFSARDEWPGI
KPDVLAGFQQQLSDDFQRTVERFLALQTMGTETARQDARALKKTVLALPMPEVDVLNGGL
EILKTVDLRQPLQNVSMPFLRLYGYLDGLVPRKVVPMLDKLWPHSESYIFAKAAHAPFIS
HPVEFCHLLVALKQRV
>sp|P13001|BIOH_ECOLI Carboxylesterase bioH;
MNNIWWQTKGQGNVHLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSRGFGALS
LADMAEAVLQQAPDKAIWLGWSLGGLVASQIALTHPERVQALVTVASSPCFSARDEWPGI
KPDVLAGFQQQLSDDFQRTVERFLALQTMGTETARQDARALKKTVLALPMPEVDVLNGGL
EILKTVDLRQPLQNVSMPFLRLYGYLDGLVPRKVVPMLDKLWPHSESYIFAKAAHAPFIS
HPAEFCHLLVALKQRV
>sp|Q1R5M2|BIOH_ECOUT Carboxylesterase bioH;
MNNIWWQTKGQGNVHLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSRGFGALS
LADMAEAVLRQAPDKAIWLGWSLGGLVASQIALTHPERVQALVTVASSPCFSARDEWPGI
KPDVLAGFQQQLSDDFQRTVERFLALQTMGTETARQDARALKKTVLALPMPEVDVLNGGL
EILKTVDLRLPLQNVSMPFLRLYGYLDGLVPRKVVPMLDKLWPHSESYIFAKAAHAPFIS
HPVEFHHLLVALKQRV
>sp|A7MGD2|BIOH_ENTS8 Carboxylesterase bioH;
MNDIWWQTTGEGNCHLVLLHGWGLNAEVWRCISQELSSHFTLHLVDLPGYGRSQGYGALT
LDEMARLVASRAPECAIWLGWSLGGLVASQVALSEPSRVDALVTVASSPCFQAGADWPGI
KPEVLSGFQRQLSEDFQRTVERFLALQTLGTETARQDARVLKSIVLAQPMPGADVLNGGL
EILKTADLREALTAWQGPFLRLYGRLDGLVLRKVAALLDARFPDSESQVFEKAAHAPFIS
HPREFCDALLALKARLANR
>sp|Q6CZL9|BIOH_ERWCT Carboxylesterase bioH;
MAALYWQTEGAGNTDLVLLHGWGLNAQVWQSMVVRLAPHFRLHLVDLPGYGRSQGFGPMP
LNDMANIVLTQAPERAVWLGWSLGGLVASQIALSAPLRVEKLITVASSPCFSAQDDWPGI
KPDVLQGFQQQLSEDFQRTVERFLALQTLGTENARQDARLLKGVVLEQPMPSVDVLNGGL
EILREADLRQPLADLTVPLLRLYGALDGLVPRKVAGRLDDEWPNSTSVVMPKAAHAPFIS
HPDAFTEQVIAFAQA
>sp|Q5QZC0|BIOH_IDILO Carboxylesterase bioH;
MSISVTCCGTGTPIVVLHGWGMNSNIWQPVVPALSEHFQLYCVDLPGFGDSVWSSENDVS
LESFIEQIMPALPPRFHLLGWSLGGLIATQIALTHSDRVMSLTTVASSPHFVESNDWAGI
KPDILEQFQQQLDSNFKKTIERFLAIQAMGSEDAREQVKQVKQLIFTKPMPDQGVLKQSL
TILQTADLRQQLPNIEVPFNRFYGRLDSLVPERAIDDISALAPESKAVVFTKSAHAPFIS
EPERFISELLKVVEN
>sp|A6TF35|BIOH_KLEP7 Carboxylesterase bioH;
MNDIWWQTIGEGDCHLVLLHGWGLNAQVWDCITPQLASHFTLHLVDLPGYGRSGGFGAMS
LEAMAQRVLEQAPPQAVWLGWSLGGLVASQVAIMRPERVQALVTVASSPCFAARDDWPGI
KPEVLAGFQQQLSDDFQRTVERFLALQTMGTESARQDARALKQAVLSLPMPSAEALNGGL
EILRTVDLRQALVRLPMPFLRLYGRLDGLVPRKIVPLLDDLWPESESILFDKAAHAPFVS
HPAAFCEPLLALKTRLG
>sp|Q5X590|BIOH_LEGPA Carboxylesterase bioH;
MNIHLDKHGQGMPLVLFHGWGFDNQIWQPIIPYLKPKYQIILVDLPGFGLTPMMDWESFK
KNLLDQLPDKFALAGWSMGGLYATRLAIEEPARVQYLINITSSPRFISDIDWPGVAEEVF
VNFYNNLSKDINKTLKEFISLQLNKMKFDFKIGNPPSPEGLAFGLEILGTWDFREQLKQI
TIPTVYLFGRLDPITPVKTMAIMEKNYPNFKYVLFNRAAHMPFLSHTDLFITMMDEFIK
>sp|A5IBW4|BIOH_LEGPC Carboxylesterase bioH;
MNIHLDKYGQGMPLVLFHGWGFDSQIWQPIIPYLKPKYQIILVDLPGFGLTPMMDWESFK
KNLLDQLPDKFALAGWSMGGLYATRLAIEEPARVQYLINITSSPRFISDVDWPGVAEEVF
VNFYNNLSKDINKTLKEFISLQLNKMKFDFKIGNPPSPEGLAFGLEILGTWDFREQLKQI
SIPTVYLFGRLDPITPAKTMAIMEKNYPNFKYVLFNRAAHMPFLSHTDLFITMMDEFIK
>sp|Q5ZVG6|BIOH_LEGPH Carboxylesterase bioH;
MNIHLDKYGQGMPLVLFHGWGFDSQIWQPIIPYLKPKYQIILVDLPGFGLTPMMDWESFK
KNLLDQLPDKFALAGWSMGGLYATRLAIEEPARVQYLINITSSPRFISDIDWPGVAEEVF
VNFYNNLSKDINKTLKEFISLQLNKMKCDFKIGNPPSPEGLAFGLEILGTWDFREQLKQI
SIPTVYLFGRLDPITPVKTMAIMEKNYPNFKYVLFNRAAHMPFLSHTDLFITIMDEFIK
>sp|Q5WW99|BIOH_LEGPL Carboxylesterase bioH;
MNIHLDKHGQGMPLVLFHGWGFDSQIWQPIIPYLKPKYQIILVDLPGFGLTPMMDWESFK
KNLFDQLPDKFALAGWSMGGLYATRLAIEEPARVQYLINITSSPRFISDIDWPGVAEEVF
VNFYNNLSKDINKTLKEFISLQLNKMKFDFKIGNPPSPEGLAFGLEILGTWDFREQLKQI
SIPTVYLFGRLDPITPAKTMAIMEKNYPNFKYVLFNRAAHMPFLSHTDLFITMMDEFIK
>sp|Q609V0|BIOH_METCA Carboxylesterase bioH;
MGLFIETSGRGPEVVLIHGWGMHGGIWSGFVPWLTDRFRVTRIDLPGHGHSPMLADWSLE
TVAGAVLEAVPRPAHWVGWSLGAMVALEAARMAPGAVASLTLLCGTPRFVAEPGWPGMEA
VTLMRFADGFLSDYEDACRRFLALQAWGMPNERELLRGVRSQLSGRPPPERPALLAGLEV
LRHADLRGVLRELPQPVQALLGRRDRLVPVELGDALARLKTGLVSHRIDDAPHVPFLTHG
ERTARLIHEFIASS
>sp|Q7N9V7|BIOH_PHOLL Carboxylesterase bioH;
MADLFWQTSDEGSRDLVLLHGWGLNAEVWRSIEMRCAPHFRLHLVDLPGYGRSQKYGPMN
LADMADEVWRYAPENALWLGWSLGGLVASRIALDHQDKVAGLITVASSPHFSAESDWPGI
KPEVLHDFEHQLSKDFQRTVERFLALQTLGTDSARQDARLLKSVVLAQPMPSVEVLHVGL
EILRTEDLRQPLAELAIPFLRIYGYLDGLVPRKIINILDEKWPRSVSAMMRHAAHAPFIS
HPDEFVGLLTEFASREVLQGR
>sp|Q6LVQ7|BIOH_PHOPR Carboxylesterase bioH;
MTTALCWQTEGQGSDLVLIHGWGMNGAVWQQLLPLLTPFYRVHWVDMPGYGHSHDISADS
IEEMAQLLLDKSPISATWLGWSLGGLVATQAALLAPERVTRLVTVASSPRFAAEGTWRGI
QPQVLDDFRRQLGDDFQLTVERFLALQAMGSPTARQDIKLLKQAVLSRPQPNPEALSIGL
RLLADVDLRAQLGDITQPWLRLYGRLDGLVPAKVAKDMDQLAPQSCRQIFAAASHAPFIS
HPEEFVQTLKDFIK
>sp|Q15N09|BIOH_PSEA6 Carboxylesterase bioH;
MHTTLKTRTVGSGPNFVLLHGWGVNSGVWQPIAKQLEQHFSVTYVDLPGFGENNQIMPKP
YDLKNLAECVANVLPENSVLAGWSLGGLVAQHVALLEPTNVKQLILIATSPKFQKGNDWA
GIDPNILQAFSQQLVKNLSKTIERFLAIQAMGSDSAKTDIRKIKNSIEASPQADIAALTA
GLDILEHVDLRDQIAALKMPIHWMLGRLDSLVPVKLQGYVQRSLAKNHSVTIFPHASHAP
FISHTEDFLIDLMENTLR
>sp|A9MMB5|BIOH_SALAR Carboxylesterase bioH;
MNDIWWQTYGEGNCHLVLLHGWGLNAEVWHCIREELGSHFTLHLIDLPGYGRSTGFGAMT
LEEMTAQVAKNAPDQAIWLGWSLGGLVASQMALIHPERVQALVTVASSPCFSAREGWPGI
KPEVLAGFQQQLSDDFERTVERFLALQTLGTETARQDARTLKSVVLAQSMPDVEVLNGGL
EILKTVDLREPLKSVNMPFLRLYGYLDGLVPRKIAPLLDTLWPHSTSQIIVKAAHAPFIS
HPAAFCQALAALKSSL
>sp|Q57IW5|BIOH_SALCH Carboxylesterase bioH;
MNDIWWQTYGEGNCHLVLLHGWGLNAEVWHCIREELGSHFTLHLVDLPGYGRSSGFGAMT
LEEMTAQVAKNAPDQAIWLGWSLGGLVASQMALTHPERVQALVTVASSPCFSAREGWPGI
KPEILGGFQQQLSDDFQRTVERFLALQTLGTETARQDARTLKSVVLAQPMPDVEVLNGGL
EILKTVDLREALKNVNMPFLRLYGYLDGLVPRKIAPLLDTLWPHSTSQIMAKAAHAPFIS
HPAAFCQALMTLKSSL
>sp|Q5PLY8|BIOH_SALPA Carboxylesterase bioH;
MNDIWWQTYGEGNCHLVLLHGWGLNAEVWHCIREELGSHFTLHLVDLPGYGRSSGFGAMT
LEEMTAQVAKNAPDQAIWLGWSLGGLVASQMALTHPERVQALVTVASSPCFSAREGWPGI
KPEILGGFQQQLSDDFQRTVERFLALQTLGTETARQDARTLKSVVLAQPMPDVEVLNGGL
EILKTVDLREALKNVNMPFLRLYGYLDGLVPRKIAPLLDTLWPHSTSQIMAKAAHAPFIS
HPAAFCQALMTLKSSL
>sp|Q8Z221|BIOH_SALTI Carboxylesterase bioH;
MNDIWWQTYGEGNCHLVLLHGWGLNAEVWHCIREELGSHFTLHLVDLPGYGRSSGFGAMT
LEEMTAQVAKNAPDQAIWLGWSLGGLVASQMALTHPERVQALVTVASSPCFSAREGWPGI
KPEILGGFQQQLSDDFQRTVERFLALQTLGTETARQDARTLKSVVLAQPMPDVEVLNGGL
EILKTVDLREALKNVNMPFLRLYGYLDGLVPRKIAPLLDTLWPHSTSQIMAKAAHAPFIS
HPAAFCQALMTLKSSL
>sp|Q8ZLI9|BIOH_SALTY Carboxylesterase bioH;
MNDIWWQTYGEGNCHLVLLHGWGLNAEVWHCIREELGSHFTLHLVDLPGYGRSSGFGAMT
LEEMTAQVAKNAPDQAIWLGWSLGGLVASQMALTHPERVQALVTVASSPCFSAREGWPGI
KPEILGGFQQQLSDDFQRTVERFLALQTLGTETARQDARTLKSVVLAQPMPDVEVLNGGL
EILKTVDLREALKNVNMPFLRLYGYLDGLVPRKIVPLLDTLWPHSTSQIMAKAAHAPFIS
HPAAFCQALMTLKSSL
>sp|Q8GHL1|BIOH_SERMA Carboxylesterase bioH;
MTALYWQTIGEGERDLVLLHGWGLNAEVWSCIQALTPHFRLHLVDLPGYGRSQGFGALSL
AQMTEIVLAAAPPQAWWLGWSLGGLVASQAALMQPQRVSGLITVASSPCFAARDEWPGIR
PDVLSGFQHQLSLDFQRTVERFLALQTLGTESARQDARQLKAVVLNQPTPSVEVLNGGLE
ILRTADLRAPLAELNLPLLRIYGYLDGLVPRKVAELLDAAWPNSTSQIVAKAAHAPFISH
PDEFVTMIEAFIAAH
>sp|A8GKT5|BIOH_SERP5 Carboxylesterase bioH;
MTALYWQTIGEGDRDLVLLHGWGLNAEVWSCMLERLTPHFRLHLVDLPGYGRSQGFAAMS
LEQMAEIVLDAAPAQAWWLGWSLGGLVASQIALTQPQRVHGLITVASSPCFAAQDDWPGI
RPEVLSGFQHQLSQDFQRTVERFLALQTLGTESARQDARLLKSVVLNQPMPSVEILNGGL
EILRTADLRQSLAGLSLPLLRIYGYLDGLVPRKVAGLLDVSWPHSSSIIIAKAAHAPFIS
QPDEFAEIIGTFVAENGICRQNAQ
>sp|Q8E8N6|BIOH_SHEON Carboxylesterase bioH;
MNATTSAHHPLHIETIGQGPDLVVIHGWGVNSAVFTPLHEQLSEYRVHYVDLPGFGLSQP
IAGNLSTWIDALINNLPTNAIWAGWSLGGLVATQAAIDYPSHIKGLITIASSPCFMAREE
EAWPGIPPQVLSMFGEQLGQNLPKTIERFLAIQAMGSETAKEDIKQLRDLVLARPLPDAA
ALTQGLDMLNQIDLRMQLSSISQPWLRIWGRLDGLVPKRVQPQMPTASHITDVMLAKASH
APFVSHRQEFLQALLPWLTQFKD
>sp|Q0HPU6|BIOH_SHESR Carboxylesterase bioH;
MNATTPAHRPQLHIDTRGQGPDLVMLHGWGVNSAVFTPLHEQLSEYRVHYVDLPGFGLSQ
PIAGDLSTWVDALIHALPANAIWAGWSLGGLVATQAAIRYPSHIQGLITIASSPCFMARE
EEAWPGIPPQVLSMFGEQLGQNLPKTIERFLAIQAMGSETAKDDIKQLRDLVLARPLPDA
AALTQGLDMLNQIDLRPQLSAIQQPWLRIWGRLDGLVPKRVQPQMPTANHITDVMLAKAS
HAPFVSHMEEFLQAITPWLAQFKD
>sp|Q31VM0|BIOH_SHIBS Carboxylesterase bioH;
MNNIWWQTKGQGNVHLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSQGFGALS
LADMAEAVLQQAPDKAIWLGWSLGGLVASQIALTHPERVQALVTVASSPCFSARDDWPGI
KPDVLAGFQQQLSDDFQRTVERFLALQTMGTETARQDARALKKTVLALPMPEVDVLNGGL
EILKTVDLRQPLQNVPMPFLRLYGYLDGLVPRKVVPMLDKLWPRSKSYIFAKAAHAPFIS
HPVEFCHLLVALKQRL
>sp|Q32AM6|BIOH_SHIDS Carboxylesterase bioH;
MNNIWWQTKGQGNVHLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSRGFGAMS
LADMAEAVLRQAPDKAIWLGWSLGGLVASQIALTHPERVQALVTVASSPCFSARDEWLGI
KPDVLAGFQQQLSDDFQRTVERFLALQTMGTETARQDARALKKTVLALPMPEVDVLNGGL
EILKTVDLRQPLQNVSMPFLRLYGYLDGLVPRKVVPMLDKLWPHSESYIFAKAAHAPFIS
HPVEFRHVLVALKQRV
>sp|Q83PW0|BIOH_SHIFL Carboxylesterase bioH;
MNNIWWQTKGQGNVHLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSRGFGALS
LADMAEAVLQQAPDKAIWLGWSLGGLVASQIALTHPERVQALVTVASSPCFSARDEWPGI
KPDVLAGFQQQLSDDFQRTVERFLALQTMGTETARQDARALKKTVLALPMPEVDVLNGGL
EILKTVDLRQPLQNVSMPFLRLYGYLDGLVPRKVVPMLDKLWPHSESYIFAKAAHAPFIS
HPVEFCHLLVALKQRVLVVSES
>sp|Q3YWL3|BIOH_SHISS Carboxylesterase bioH;
MNNIWWQTKGQGNVHLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSQGFGALS
LADMAEAVLQQAPDKAIWLGWSLGGLVASQIALTHPERVQALVTVASSPCFSARDDWPGI
KPDVLAGFQQQLSDDFQRTVERFLALQTMGTETARQDARALKKTVLALPMPEVDVLNGGL
EILKTVDLRQPLQNVPMPFLRLYGYLDGLVPRKVVPMLDKLWPRSKSYIFAKAAHAPFIS
HPVEFCHLLVALKQRV
>sp|Q2NQH6|BIOH_SODGM Carboxylesterase bioH;
MVSLFWQTTGTGDRDLVLLHGWGLNAEVWSYIVPRLATHFRLHLVDLPGYGRSRGYGALT
LEEMAEEVASRAPHGALWLGWSLGGLVATTVARRCPHAVAGLVTVASSPRFCADGDWPGI
RPEVLEGFARELRQDFTRTVSRFLGLQTLGTASARQDTRWLKSVVLAHPAPAIEVLTGGL
ALLRTSDVRKALDQLDVPLLRLYGYLDGLVPRKVVPLVDELSTASHSIVFAGAAHAPFIS
HPVPFCQALCDFSQLES
>sp|Q9KNL4|BIOH_VIBCH Carboxylesterase bioH;
MTMALYWQVSGQGQDLVLVHGWGMNGAVWQQTAQALSDHFRVHVVDLPGYGHSAEQHAAS
LEEIAQALLEHAPRNAIWVGWSLGGLVATHMALHHSDYVSKLVTVASSPKFAAQGSWRGI
QPDVLTAFTDQLVADFQLTIERFMALQAMGSPSARQDVKVLKQAVLSRPMPNPQSLLAGL
TMLAEVDLRDELQHISVPMLRLYGRLDGLVPAKVARDLNHLAPYSEAFMFDQSSHAPFMT
EAEAFCQQLIEFATR
>sp|Q5E8N3|BIOH_VIBF1 Carboxylesterase bioH;
MTTPLYWQTEGEGSDLVLIHGWGMNGAVWQTTSEKLSQHYRVHTVDLSGYGHSAELGCAD
FDEMVKQVLAQAPKKAAWLGWSLGGLIATKAALTSPERVSQLITVASSPRFSAEKGWRGI
KPLVLSQFTEQLKTDFTLTVERFMALQAMGSPNAKQDIKLVKKAVFSRPMPDQQALATGL
MILADIDLREAVSQLSMPVCRMYGRLDGLVPIKVAHDMDELMPNSAKIVFEQASHAPFIS
HNDEFISELRTFLNQHA
>sp|A7MST3|BIOH_VIBHB Carboxylesterase bioH;
MSTNLHWQSFGQGPDLVLLHGWGMNGAVWQQTVESLQPYFRVHVVDLPGYGHSAESHAED
LAKIADLVLQDAPEKAVWLGWSLGGLVATHIALNAPQRVSKLITVASSPKFAAERPWRGI
QPNVLTAFTDQLLEDFSVTIERFMALQAMGSPSARKDVKQLKQAVLSRPQPNPDSLLVGL
NILADVDLRDALTSLSMPMLRLYGRLDGLVPIKVASDLNEQLPSTQQFVFNQSSHAPFMT
EHEAFCLQVREFAA
>sp|Q87TC2|BIOH_VIBPA Carboxylesterase bioH;
MSTNLHWQSFGQGPDLVLLHGWGMNGAVWQQTVESLQADFCVHVVDLPGYGFSAEHHGED
LAQIAAMVLKDAPEKAVWLGWSLGGLVATHIALNAPQRVSKLITVASSPKFAAEKPWRGI
QPNVLSAFTSQLLEDFSLTIERFMALQAMGSPSARKDVKQLKQAVLSRPQPNPESLLVGL
NILADVDLRDALISLTMPMLRLYGRLDGLVPIKVATDLSQQLPHTQQFVFSQSSHAPFMT
EHDEFCAQVRDFAQD
>sp|Q8DDU4|BIOH_VIBVU Carboxylesterase bioH;
MSTDLHWQTQGQGPDLVLLHGWGMNGAVWQQVVERLELHFRLHVVDLPGYGHSAHLHAAS
LEEIAQQLLEHAPKQAIWVGWSLGGLVATHMALHHADYVSKLVTVASSPKFAAEARWRGI
QPQVLSAFTEQLSEDFHTTVERFMALQAMGSPSARQDVKNLKQAVFSRPQPNPQSLLAGL
QMLAEVDLRDHLPHLTMPMLRLYGRLDGLVPIKVAQDLEKVLPASEQFIFTQSSHAPFIT
EPESFCHQLLSFAGK
>sp|Q7MPY0|BIOH_VIBVY Carboxylesterase bioH;
MSTDLHWQTQGQGPDLVLLHGWGMNGAVWQQVVERLEPHFRLHVVDLPGYGHSAHLHAAS
LEEIAQQLLEHAPKQAIWVGWSLGGLVATHMALHHADYVSKLVTVASSPKFAAEARWRGI
QPQVLSAFTEQLSEDFHITVERFMALQAMGSPSARQDVKNLKQAVFSRPQPNPQSLLAGL
QMLAEVDLRDHLPHLTMPMLRLYGRLDGLVPIKVAQDLEKALPASEQFIFTQSSHAPFIT
EPESFCHQLLSFAGK
>sp|Q8D1X1|BIOH_WIGBR Carboxylesterase bioH;
MKPFFWRIIGSGSVNLVFIHGWGLNSCIWNNIIIILSNYFKLHLVDLPGYGKNILYKEYS
FSKITEIIACKSPKKSILIGWSLGGLIATNISIVYPEKFKGLIIVSSSPCFCEKKDWPGI
KKEILNNFSFQLKNDFHNTVKKFFNIQFLGTKKNNNEIKKLKNIFFRQKEPSYKTLSSGL
KILKNIDIRNYLKYIKIPTLRIYGNLDVIVPVKIIPIIKKLQNFNINKNIIIPSASHAPF
LSHPFLFCKIIKYFIKKFN
>sp|Q8PQE0|BIOH_XANAC Carboxylesterase bioH;
MHIDVIGHGPALVLLHGWALHGGVFAPLVERLAPHYQLHLVDLPGHGFSRDDSTPLALPY
VVAEIAAATPPAVWLGWSLGGLFALHAAATLPQVRGLAMIAATPRFVRGSDWPSAVQREV
FVQFGVELSRDYRGTLERFLALDTLGSAHARSELRSLRETLTARGEPAPEALQQGLTLLE
RTDLRRTVPQLARPSLWIAGQRDRLVPAAGMHAAAALSPHAQALTIAGGGHAPFLGHADQ
VSEALQRFVASVP
>sp|Q4UZP1|BIOH_XANC8 Carboxylesterase bioH;
MHIDVIGHGPALVLLHGWALHGGVFAPLVERLAPHYQLHLVDLPGHGFSHDDTTPLALPH
VVAAIAAATPAAVWVGWSLGGLFALHAAATQPQVRALAMIAATPRFVRGSDWPDAVEREV
FVQFGQDLARDYRGTLDRFLALDTLGSAHARSELRSLRETLTARGEPAASALQDGLGLLE
RTDLRRALATLARPSLWIAGQRDRLVPAAGMHAAAARAPHAQALTIDGGGHAPFLGHADQ
VAEALHRFVAALP
>sp|Q8PDF3|BIOH_XANCP Carboxylesterase bioH;
MHIDVIGHGPALVLLHGWALHGGVFAPLVERLAPHYQLHLVDLPGHGFSHDDTTPLALPH
VVAAIAAATPAAVWVGWSLGGLFALHAAATQPQVRALAMIAATPRFVRGSDWPDAVEREV
FVQFGQDLARDYRGTLDRFLALDTLGSAHARSELRSLRETLTARGEPAASALQDGLGLLE
RTDLRRALATLARPSLWIAGQRDRLVPAAGMHAAAARAPHAQALTIDGGGHAPFLGHADQ
VAEALHRFVAALP
>sp|Q2P907|BIOH_XANOM Carboxylesterase bioH;
MHIDVIGHGPALVLLHGWALHGGVFAPLVERLAPHYQLHLVDLPGHGFSRDDSTPLALPY
VVAEIAAATPPAVWLGWSLGGLFALHAAATLPQVRGLAMIAATPRFVRGSDWPDAVQREL
FVQFGTELSRDYRGTLERFLALDTLGSAHARSELRSLRETLTARGEPAPEALQQGLSLLE
RTDLRRALPQLARPSLWIAGQRDRLVPAAGMHAAAALSPHAQALTIAGGGHAPFLGHADQ
VSEALQRFVASVP
>sp|Q5H6D1|BIOH_XANOR Carboxylesterase bioH;
MHIDVIGHGPALVLLHGWALHGGVFAPLVERLAPHYQLHLVDLPGHGFSRDDSTPLALPY
VVAEIAAATPPAVWLGWSLGGLFALHAAATLPQVRGLAMIAATPRFVRGSDWPDAVQREL
FVQFGTELSRDYRGTLERFLALDTLGSAHARSELRSLRETLTARGEPAPEALQQGLSLLE
RTDLRRALPQLARPSLWIAGQRDRLVPAAGMHAAAALSPHAQALTIAGGGHAPFLGHADQ
VSEALQRFVASVP
>sp|Q9PDM3|BIOH_XYLFA Carboxylesterase bioH;
MYIEVTGYGPALVLIHGWAMHSGVFAPLVEQLRAHHTLYLVDLPGHGYNHTTLTPLALPH
VVHAIAAATPPAVWLGWSLGGLFALHAAATLPQVRGLIMLAATPCFVRREDWPHAVEVSI
FTQFAEDLKQNYTETINRFLALDTLGSTYAQSELRQLRQILNARHTPNTATLQAGLELLA
HTDLRRAVIDLTPPSLWIAGQRDRLVPAASIHAATALAPSGQTELLTITGGGHAPFLSHA
NQMTAALQHFIATLP
>sp|Q87DT3|BIOH_XYLFT Carboxylesterase bioH;
MYIEVTGYGPALVLIHGWAMHSGVFAPLVEQLRPHHTLYLVDLPGHGYNHTTPTPLALPQ
VVHAIAAATPPAVWLGWSLGGLFALHAAATLPQVRGLIMLAATPCFVRREDWPHAVEVSI
LTQFAQDLKQNYTETINRFLALDTLGSTHAQSELRQLRKILNARHTPNTATLQAGLELLA
HTDLRRALIDLTPPSLWIAGQRDRLVPAASIQAATVLAPSDQTELLTITGGGHAPFLSHA
NQMTAALQHFIATLP
>sp|A1JSF8|BIOH_YERE8 Carboxylesterase bioH;
MKQLYWNICGEGDCDLVLLHGWGLNAGVWHCIIDRLTPHFRLHLVDLPGYGRSTEFGAMS
LSEMAEIVLQQAPQQAIWLGWSMGGLVASQIALSHPERVRGLITVSSSPCFTAHDEWPGI
RPEVLAGFQQQLSEDFQRTVERFLALQTLGTESARQDARLLKAVVLQHQMPEVAVLTGGL
DILRTADLREELADCSLPFLRIYGYLDGLVPRKVAALLNSQWPHTQSVVMPGSAHAPFVS
HPEAFSQLVVDFAQQSNT
>sp|A7FNV8|BIOH_YERP3 Carboxylesterase bioH;
MKQLYWYTCGEGDCDLVLLHGWGLNSGVWHCIIDRLAPHFRLHLVDLPGYGRSQDYGAMS
LADMAERVAQQAPKQALWLGWSMGGLVASQIALSQPECVRGLITVSSSPCFTARDEWPGI
KPEVLAGFQHQLSDDFHRTVERFLALQTLGTESSRQDARLLKSVVLQHQMPDVEVLTGGL
AILRTADLRTALAGFTLPFMRVYGHLDSLVPRKVASLLDSAWPQTQSVVMQGAAHAPFIS
HPNDFAKLILNFAEENKK
>sp|Q74Y45|BIOH_YERPE Carboxylesterase bioH;
MKQLYWYTCGEGDCDLVLLHGWGLNSGVWHCIIDRLAPHFRLHLVDLPGYGRSQDYGAMS
LADMAERVAQQAPKQALWLGWSMGGLVASQIALSQPECVRGLITVSSSPCFTARDEWPGI
KPEVLAGFQHQLSDDFHRTVERFLALQTLGTESSRQDARLLKSVVLQHQMPDVEVLTGGL
AILRTADLRTALAGFTLPFMRVYGHLDSLVPRKVASLLDSAWPQTQSVVMQGAAHAPFIS
HPNDFAKLILNFAEENKK
>sp|Q664J8|BIOH_YERPS Carboxylesterase bioH;
MKQLYWYTCGEGDCDLVLLHGWGLNSGVWHCIIDRLAPHFRLHLVDLPGYGRSQDYGAMS
LADMAERVAQQAPKQALWLGWSMGGLVASQIALSQPECVRGLITVSSSPCFTARDEWPGI
KPEVLAGFQHQLSDDFHRTVERFLALQTLGTESSRQDARLLKSVVLQHQMPDVEVLTGGL
EILRTADLRTALSGFTLPFMRVYGHLDSLVPRKVASLLDSAWPQTQSVVMQGAAHAPFIS
HPNDFAKLILNFAEENKK

Формулировка функции белка	Строка запроса	Количество найденных документов
Carboxylesterase bioH	((([swissprot-Description:Carboxylesterase] & [swissprot-Description:bioH]) \| [swissprot-Description:Carboxylesterase bioH]) & [swissprot-Taxonomy:gammaproteobacteria])	55
Biotin synthesis protein bioH	((((([swissprot-Description:Biotin] & [swissprot-Description:synthesis]) & [swissprot-Description:protein]) & [swissprot-Description:bioH]) \| [swissprot-Description:Biotin synthesis protein bioH]) & [swissprot-Taxonomy:gammaproteobacteria])	55
Carboxylesterase	([swissprot-Description:Carboxylesterase] & [swissprot-Taxonomy:gammaproteobacteria])	57
Biotin synthesis protein	(((([swissprot-Description:Biotin] & [swissprot-Description:synthesis]) & [swissprot-Description:protein]) \| [swissprot-Description:Biotin synthesis protein]) & [swissprot-Taxonomy:gammaproteobacteria*])	60
Сarboxylesterase activity with a preference for short chain fatty acid esters		0
Carboxylesterase, thioesterase	((([swissprot-Comment:thioesterase] > parent ) & ([swissprot-Comment:carboxylesterase] > parent )) & [swissprot-Taxonomy:gammaproteobacteria*])	55
A complex with CoA, carboxylesterase	carboxylesterase	0
A precursor in biotin biosynthesis,carboxylesterase		0

Учебный сайт Люды Андреевой

Краткое сравнение поисковых систем SRS, MRS и UniProt

Поиск по таксономии в SRS

Поиск в SRS белков с функцией, сходной с BIOH_ECOLI

Аминокислотные последователности

Мной также были выполнены дополнительные задания.